Alethro
Alethro›Drug index›Zepbound
Weight loss / GLP-1

Zepbound costs $75–$200/month.

Zepbound (tirzepatide) costs $25–$455/month for most insured patients depending on plan tier and deductible status, with prior authorization typically required and LillyDirect self-pay available at $349/month for eligible commercial-plan patients.

Estimates only. Verify with your pharmacy and insurer before filling. Not medical, financial, or insurance advice.

Cost calculatorEstimates only · verify before filling
Step 1 of 3Drug

What are you filling?

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$1,086
Manufacturer list
$349
LillyDirect Self-Pay self-pay
$75–$200
Typical with insurance
Tier 3
Most formularies
Where to fill

Zepbound prices by source

Manufacturer list (cash, no insurance)
Published list price · 30-day supply
$1,086
LillyDirect Self-Pay
Eligible commercial-insured patients
$349
Check eligibility ↗
Costplus Drug Company
Brand-only; no generic available yet
Not stocked
Walmart $4 generic list
Brand-only; no generic available yet
Not eligible
GoodRx
Coupon-based pricing varies by pharmacy and ZIP
~$549

Sources: manufacturer published pricing · Costplus Drug Co. catalog · Walmart $4 list · GoodRx public pricing.

Commercial insurance

Your cost by plan

Tier from each carrier’s 2026 formulary — source documents linked on each plan card below. Use the calculator above for a personalized estimate based on your deductible state.

Blue Cross Blue Shield Employer PPO
Illinois Blue Choice PPO
Tier 3PA required
~$60/mo
See formulary ↗
Blue Cross Blue Shield Employer HMO
Texas Blue Advantage HMO
Tier 3PA required
~$75/mo
See formulary ↗
Aetna HDHP / HSA
Choice POS II HSA
Tier 3PA required
~$0/mo
See formulary ↗
UnitedHealthcare Employer PPO
Choice Plus PPO
Tier 3PA required
~$70/mo
See formulary ↗
Kaiser Permanente Employer HMO
Signature HMO
Tier 3PA required
~$50/mo
See formulary ↗
Cigna Employer PPO
Open Access Plus
Tier 3PA required
~$65/mo
See formulary ↗
Anthem Marketplace Silver
Silver 4500/40 Marketplace
Tier 3PA required
~$95/mo
See formulary ↗
Blue Shield of California Employer HMO
Access+ HMO
Tier 3PA required
~$60/mo
See formulary ↗
Anthem BCBS New York Employer HMO
Pathway HMO
Tier 3PA required
~$55/mo
Carrier page ↗
Florida Blue Marketplace HMO
myBlue HMO
Tier 3PA required
~$65/mo
Carrier page ↗
BCBS Michigan Employer PPO
Community Blue PPO
Tier 3PA required
~$65/mo
See formulary ↗
Independence Blue Cross Employer PPO
Personal Choice PPO
Tier 3PA required
~$70/mo
See formulary ↗
Humana Employer PPO
ChoiceCare PPO (Commercial)
Tier 3PA required
~$75/mo
Carrier page ↗
Ambetter (Centene) Marketplace Silver
Balanced Silver
Tier 3PA required
~$80/mo
See formulary ↗
Oscar Health Marketplace Bronze
Bronze Classic
Tier 3PA required
~$90/mo
Carrier page ↗
Kaiser Permanente Employer HMO
Mid-Atlantic HMO (MD/VA/DC)
Tier 3PA required
~$45/mo
Carrier page ↗
CareFirst BCBS Employer HMO
BlueChoice HMO (DC/MD/VA)
Tier 3PA required
~$60/mo
See formulary ↗
Savings program

LillyDirect Self-Pay for Zepbound

What you pay

$349/mo
Subject to eligibility · 30-day supply

Eligibility

  • Commercial insurance covering Zepbound
  • Not eligible: Medicare, Medicaid, TRICARE, VA
  • US residents 18+
Enroll at LillyDirect ↗
FAQ

Zepbound cost questions

How much does Zepbound cost with insurance?
Most commercially insured patients pay $25–$455/month for Zepbound depending on plan tier (Tier 3 typical) and deductible state. The manufacturer's LillyDirect Self-Pay program offers vials at $349/month for eligible commercial-plan patients regardless of coverage.
What is the cheapest way to get Zepbound?
LillyDirect Self-Pay vials at $349/month are the cheapest predictable option for most patients. Insurance can beat this when Zepbound is covered as a Tier 2/3 weight-loss drug and you've met your deductible, but coverage for weight loss is inconsistent across employer plans.
Is there a generic for Zepbound?
No. Zepbound (tirzepatide) is a brand-name GLP-1/GIP agonist with no generic available. The earliest possible generic competition is ~2036 based on current patent expirations.
What is LillyDirect Self-Pay for Zepbound?
LillyDirect is Eli Lilly's direct-to-consumer pharmacy. Zepbound vials are available at $349/month for the lowest dose, with all doses available without insurance for eligible patients. Pen formulations are not currently in the self-pay program.
How does Zepbound compare to Wegovy?
Zepbound (tirzepatide) and Wegovy (semaglutide) are both FDA-approved for chronic weight management. Zepbound has shown larger average weight loss in head-to-head trials. Pricing is similar; insurance coverage and prior auth requirements vary by plan.
Why does my insurance not cover Zepbound?
Many employer plans exclude weight-loss medications from coverage entirely, even if Zepbound is on the formulary. Check your specific plan's coverage policy — Zepbound for type 2 diabetes (under brand name Mounjaro) has wider coverage.
What insurance plans cover Zepbound?
Coverage varies significantly by employer. BCBS, UnitedHealthcare, and Aetna commercial plans frequently cover Zepbound at Tier 3 with prior auth. Medicare and Medicaid do not cover weight-loss drugs. See the insurance breakdown above for verified plan coverage.
What if my Zepbound prior authorization is denied?
Options: (1) appeal with BMI documentation and prior weight-loss attempts, (2) switch to Wegovy if it's covered on your plan, (3) use LillyDirect Self-Pay at $349/month, or (4) explore the manufacturer's savings card if applicable to your coverage type.
Related medications

See how Zepbound compares

Wegovy cost
2026 prices & plan tiers
Mounjaro cost
2026 prices & plan tiers
Ozempic cost with insurance
2026 prices & plan tiers
Data sources

Source URLs for Zepbound have not yet been manually verified. Estimates above are modeled from public pricing patterns and manufacturer-published list prices.

  • • Manufacturer published pricing pages
  • • NADAC National Average Drug Acquisition Cost
  • • Carrier-published formulary tiers (where known)
  • • Cost Plus Drugs / mail-order public pricing
  • • FDA Orange Book (generic availability)
Alethro

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Disclosure

Estimates only. Verify with your pharmacy and insurer before filling. Alethro is not medical, financial, or insurance advice.

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© 2026 ArcLine Ventures, LLC. Pricing estimates only — not medical advice.